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After endothelial passage IGF-I redistributes to soluble IGFBPs in the extravascular fluids or IGFBPs bound on extracellular matrix or cell surfaces (111)

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In one survey of 1418 ME/CFS patients (43), it was found that 98.5% (n=1397) of the ME/CFS participants struggled with performing daily tasks and more than half (n=775) were completely unable to complete their usual activities

Considering the same chain of events in humans as in the models used, this is even more emphasized because NaBPC157 has a salutary effect even if applied when stress pathology is already advanced (e.g